Quantum Backrooms is a horror game in which the player explores eerie rooms. A quantum computer has been used to create a horror video game called - and it's available to play online. Peculiarities of quantum objects have long inspired philosophers and artists, and now game developers are getting the bug too. James Wootton at Moth Quantum and his colleagues developed, a horror game with labyrinthine levels generated by a real quantum computer . The game draws inspiration from "the Backrooms," a horror legend developed on internet forums that consists of moving through a series of endless rooms.

Mission critical (MC) applications such as defense operations, energy management, cybersecurity, and aerospace control require reliable, deterministic, and low-latency decision making under uncertainty. Although the classical Machine Learning (ML) approaches are effective, they often struggle to meet the stringent constraints of robustness, timing, explainability, and safety in the MC domains. Quantum Artificial Intelligence (QAI), the fusion of machine learning and quantum computing (QC), can provide transformative solutions to the challenges faced by classical ML models. In this paper, we provide a comprehensive exploration of QAI for MC systems. We begin with a conceptual background to quantum computing, MC systems, and quantum machine learning (QAI). We then examine the core mechanisms and algorithmic principles of QAI in MC systems, including quantum-enhanced learning pipelines, quantum uncertainty quantification, and quantum explainability frameworks. Subsequently, we discuss key application areas like aerospace, defense, cybersecurity, smart grids, and disaster management, focusing on the role of QA in enhancing fault tolerance, real-time intelligence, and adaptability. We provide an exploration of the positioning of QAI for MC systems in the industry in terms of deployment. We also propose a model for management of quantum resources and scheduling of applications driven by timeliness constraints. We discuss multiple challenges, including trainability limits, data access, and loading bottlenecks, verification of quantum components, and adversarial QAI. Finally, we outline future research directions toward achieving interpretable, scalable, and hardware-feasible QAI models for MC application deployment.

In this paper, we explore the potential of quantum computing in enhancing malware detection through the application of Quantum Machine Learning (QML). Our main objective is to investigate the performance of the Quantum Support Vector Machine (QSVM) algorithm compared to SVM. A publicly available dataset containing raw binaries of Portable Executable (PE) files was used for the classification. The QSVM algorithm, incorporating quantum kernels through different feature maps, was implemented and evaluated on a local simulator within the Qiskit SDK and IBM quantum computers. Experimental results from simulators and quantum hardware provide insights into the behavior and performance of quantum computers, especially in handling large-scale computations for malware detection tasks. The work summarizes the practical experience with using quantum hardware via the Qiskit interfaces. We describe in detail the critical issues encountered, as well as the fixes that had to be developed and applied to the base code of the Qiskit Machine Learning library. These issues include missing transpilation of the circuits submitted to IBM Quantum systems and exceeding the maximum job size limit due to the submission of all the circuits in one job.

Quantum machine learning (QML) models conventionally rely on repeated measurements (shots) of observables to obtain reliable predictions. This dependence on large shot budgets leads to high inference cost and time overhead, which is particularly problematic as quantum hardware access is typically priced proportionally to the number of shots. In this work we propose Y ou Only Measure Once (Y omo), a simple yet effective design that achieves accurate inference with dramatically fewer measurements, down to the single-shot regime. Y omo replaces Pauli expectation-value outputs with a probability aggregation mechanism and introduces loss functions that encourage sharp predictions. Our theoretical analysis shows that Y omo avoids the shot-scaling limitations inherent to expectation-based models, and our experiments on MNIST and CIFAR-10 confirm that Y omo consistently outperforms baselines across different shot budgets and under simulations with depolarizing channels. By enabling accurate single-shot inference, Y omo substantially reduces the financial and computational costs of deploying QML, thereby lowering the barrier to practical adoption of QML. Quantum computing (Nielsen & Chuang, 2010) has emerged as a promising paradigm for advancing computational capabilities beyond the classical regime. Unlike classical machine learning, however, QML inherently involves probabilistic measurement outcomes. To obtain reliable outputs, QML models typically require repeated circuit executions, aggregating many measurement shots to estimate expectation values of observables. This reliance on repeated measurements constitutes one of the fundamental distinctions between classical and quantum machine learning.

A fully quantum reinforcement learning framework is developed that integrates a quantum Markov decision process, dynamic circuit-based qubit reuse, and Grover's algorithm for trajectory optimization. The framework encodes states, actions, rewards, and transitions entirely within the quantum domain, enabling parallel exploration of state-action sequences through superposition and eliminating classical subroutines. Dynamic circuit operations, including mid-circuit measurement and reset, allow reuse of the same physical qubits across multiple agent-environment interactions, reducing qubit requirements from 7*T to 7 for T time steps while preserving logical continuity. Quantum arithmetic computes trajectory returns, and Grover's search is applied to the superposition of these evaluated trajectories to amplify the probability of measuring those with the highest return, thereby accelerating the identification of the optimal policy. Simulations demonstrate that the dynamic-circuit-based implementation preserves trajectory fidelity while reducing qubit usage by 66 percent relative to the static design. Experimental deployment on IBM Heron-class quantum hardware confirms that the framework operates within the constraints of current quantum processors and validates the feasibility of fully quantum multi-step reinforcement learning under noisy intermediate-scale quantum conditions. This framework advances the scalability and practical application of quantum reinforcement learning for large-scale sequential decision-making tasks.

Quantum generative modeling using quantum circuit Born machines (QCBMs) shows promising potential for practical quantum advantage. However, discovering ansätze that are both expressive and hardware-efficient remains a key challenge, particularly on noisy intermediate-scale quantum (NISQ) devices. In this work, we introduce a prompt-based framework that leverages large language models (LLMs) to generate hardware-aware QCBM architectures. Prompts are conditioned on qubit connectivity, gate error rates, and hardware topology, while iterative feedback, including Kullback-Leibler (KL) divergence, circuit depth, and validity, is used to refine the circuits. We evaluate our method on a financial modeling task involving daily changes in Japanese government bond (JGB) interest rates. Our results show that the LLM-generated ansätze are significantly shallower and achieve superior generative performance compared to the standard baseline when executed on real IBM quantum hardware using 12 qubits. These findings demonstrate the practical utility of LLM-driven quantum architecture search and highlight a promising path toward robust, deployable generative models for near-term quantum devices.

IQM Germany Abstract--Quantum policy evaluation (QPE) is a reinforcement learning (RL) algorithm which is quadratically more efficient than an analogous classical Monte Carlo estimation. It makes use of a direct quantum mechanical realization of a finite Markov decision process, in which the agent and the environment are modeled by unitary operators and exchange states, actions, and rewards in superposition. Previously, the quantum environment has been implemented and parametrized manually for an illustrative benchmark using a quantum simulator . In this paper, we demonstrate how these environment parameters can be learned from a batch of classical observational data through quantum machine learning (QML) on quantum hardware. The learned quantum environment is then applied in QPE to also compute policy evaluations on quantum hardware. Our experiments reveal that, despite challenges such as noise and short coherence times, the integration of QML and QPE shows promising potential for achieving quantum advantage in RL.

Qiskit is an open-source quantum computing framework that allows users to design, simulate, and run quantum circuits on real quantum hardware. We explore post-training techniques for LLMs to assist in writing Qiskit code. We introduce quantum verification as an effective method for ensuring code quality and executability on quantum hardware. To support this, we developed a synthetic data pipeline that generates quantum problem-unit test pairs and used it to create preference data for aligning LLMs with DPO. Additionally, we trained models using GRPO, leveraging quantum-verifiable rewards provided by the quantum hardware. Our best-performing model, combining DPO and GRPO, surpasses the strongest open-source baselines on the challenging Qiskit-HumanEval-hard benchmark.

A fundamental limitation of probabilistic deep learning is its predominant reliance on Gaussian priors. This simplistic assumption prevents models from accurately capturing the complex, non-Gaussian landscapes of natural data, particularly in demanding domains like complex biological data, severely hindering the fidelity of the model for scientific discovery. The physically-grounded Boltzmann distribution offers a more expressive alternative, but it is computationally intractable on classical computers. To date, quantum approaches have been hampered by the insufficient qubit scale and operational stability required for the iterative demands of deep learning. Here, we bridge this gap by introducing the Quantum Boltzmann Machine-Variational Autoencoder (QBM-VAE), a large-scale and long-time stable hybrid quantum-classical architecture. Our framework leverages a quantum processor for efficient sampling from the Boltzmann distribution, enabling its use as a powerful prior within a deep generative model. Applied to million-scale single-cell datasets from multiple sources, the QBM-VAE generates a latent space that better preserves complex biological structures, consistently outperforming conventional Gaussian-based deep learning models like VAE and SCVI in essential tasks such as omics data integration, cell-type classification, and trajectory inference. It also provides a typical example of introducing a physics priori into deep learning to drive the model to acquire scientific discovery capabilities that breaks through data limitations. This work provides the demonstration of a practical quantum advantage in deep learning on a large-scale scientific problem and offers a transferable blueprint for developing hybrid quantum AI models.

Quantum machine learning (QML) presents potential for early industrial adoption, yet limited access to quantum hardware remains a significant bottleneck for deployment of QML solutions. This work explores the use of classical surrogates to bypass this restriction, which is a technique that allows to build a lightweight classical representation of a (trained) quantum model, enabling to perform inference on entirely classical devices. We reveal prohibiting high computational demand associated with previously proposed methods for generating classical surrogates from quantum models, and propose an alternative pipeline enabling generation of classical surrogates at a larger scale than was previously possible. Previous methods required at least a high-performance computing (HPC) system for quantum models of below industrial scale (ca. 20 qubits), which raises questions about its practicality. We greatly minimize the redundancies of the previous approach, utilizing only a minute fraction of the resources previously needed. We demonstrate the effectiveness of our method on a real-world energy demand forecasting problem, conducting rigorous testing of performance and computation demand in both simulations and on quantum hardware. Our results indicate that our method achieves high accuracy on the testing dataset while its computational resource requirements scale linearly rather than exponentially. This work presents a lightweight approach to transform quantum solutions into classically deployable versions, facilitating faster integration of quantum technology in industrial settings. Furthermore, it can serve as a powerful research tool in search practical quantum advantage in an empirical setup.